This is my best layout yet. Start Xpadder, and then load the files in this download.

PS3(360) Buttons:

Buttons 1:
START - (tap) Esc: Escape/ Game Menu (hold) C: Character (hold 1 sec) ,: Crown Store
SELECT(Back) - (tap) Alt (hold) K: Skills (hold 1 sec) =: Champion
L1(LB) - Right mouse button: Block
L2(LT) - Hold for buttons 2
L3(LS) - CTRL: Crouch/ Sneak
L-STICK - ASDW: Move
R1(RB) - Left mouse button: Attack
R2(RT) - Shift: Sprint
R3(RS) - `: Swap Weapon
R-STICK - Mouse: Camera
TRIANGLE(Y) - Space: Jump
SQUARE(X) - 1: Ability 1
CROSS(A) - 2: Ability 2
CIRCLE(B) - 3: Ability 3
D-PAD UP - H: Horse
D-PAD DOWN - (tap) Tab: Switch Targets (hold) Y: Command Pet
D-PAD LEFT - Q: Quick Menu
D-PAD RIGHT - E: Activate/ Interact with Environment

Buttons 2:
START - (tap) J: Journal (hold) G: Guilds (hold 1 sec) L: Alliance War
SELECT(Back) - (tap) M: Map (hold) P: Group (hold 1 sec) O: Contacts
L1(LB) - Right mouse button: Block
L2(LT) - Blank (Held Button)
L3(LS) - T: Toggle Quest (Recommend binding to Wak/Run. Will still swap quests inside the journal.)
L-STICK - ASDW: Move
R1(RB) - Left mouse button: Attack
R2(RT) - X: Synergy
R3(RS) - Z: Draw/Sheath Weapon
R-STICK - Mouse: Camera
TRIANGLE(Y) - Mouse Button 5: Dodge/ Roll (Bind in controls menu and turn off double tab dodge)
SQUARE(X) - 4: Ability 4
CROSS(A) - 5: Ability 5
CIRCLE(B) - R: Ultimate
D-PAD UP - Mouse Scroll Up
D-PAD DOWN - Mouse Scroll Down
D-PAD LEFT - F: Activate/ Interact with Player
D-PAD RIGHT - (tap) I: Inventory (hold) U: Collections (hold 1 sec) ': Mail (hold 2 sec) N: Notifications

I use this for the PS3 controller: XInput Wrapper for DS3 and Play.com USB Dual DS2 Controller