The issue with pop-up tooltips seems like background is hidden unintentionally via an addon...

Maybe :SetAlpha(1) or :SetHidden(true) is being set incorrectly by one addon while another addon is attempting to display their portion of the tool-tip. You would need to go through your addons to locate the ones that add data or handle any aspect of the tool-tips.

Is it just tool-tips of items or tool-tips of food/reagents, etc. Narrowing it down could help a lot to resolve the issue with your tool-tips as you could then further eliminate addons that process those particular tool-tips.

The issue with broken/non-functioning key-binds sounds really similar to the Esc key bug, at least to me...

Could it possibly be due to input lag when hitting the key-bind that upsets the function?

Perhaps transitioning from one item to another whilst using the key-bind is a cause to the Interact key-bind ceasing to function?

Do you get any disconnects from 'spamming'? I think it would be interesting if there was found to be a correlation between the two.

I wonder if the key-bind issue can be reproduced without addons.

Of course, due to my limited knowledge of lua I could be talking out of my arse :p

no, no disconnects. but i cant see this issue for a few days, mby some updates of other addons fix it

issues come back yesterday
still the same with WITHDRAW/DEPOSIT by hotkey, and with undeletable empty mails, this time one difference - no crash on /reloadui

im not given up.. will digger more and deeply :o

Non deletable empty mails appeared for me sometimes too. But only if I had enabled the Wyykyyd's mail return bot AND Mailr at the same time if I remember right.
And the only mails I couldn#t delete were the blue ones from MaiLr then.

for mails i have MailR and PostMaster Altered
blue mails from MailR always safe, i need to delete usual mails like reward for Worthy in cyrodiil but i cant sometimes...

the same again...

Shouldn't be the case since 1/2/2015. My last update to MailBox disables certain features if I detect MailR running.

Confirmed. Didn't have this error anymore since some weeks now.