As Sharlikran said it should be your PC or your browser/antivirus tools blocking the files somehow or is there an explicit message that shows that ESOUi blocks your file upload/download?
Could you show us a screenshot of the block / error message and which file/Addon you wanted to upload/download?
Does the addon's zip file contain any executable files .exe/.dmg/.dll/.bat or excel .xlsx/xlsm/xls or other executable script files?
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