Yes, please, make automatic addon profile switches upon zone change in order to give you endless loading screens if an addon refuses to work properly or to always reload the ui if you just ARE already in cyrodiil and change the zone to a subzone of cyrodiil
It's 1 keyboard hit of the ESC key and 3 clicks to change the addon profile (if you got no automatic reloadui on profile switch enabled), or 4 clicks with your mouse alternatively.
I guess this is as much comfortable and easy going as it should be.